the effect of am281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdwal in mice
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The effect of AM281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice
Abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. Endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of AM281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. Cognition was evaluated by using the object recognition task. The novel object recogni...
متن کاملthe effect of am281, a cannabinoid antagonist, on memory performance during spontaneous morphine withdrawal in mice
abrupt cessation of morphine leads to withdrawal signs and cognitive deficits. endocannabinoid system is activated during withdrawal; therefore, the aim of the present study was to assess the effects of am281, cannabinoid antagonist/inverse agonist, on memory deficit following spontaneous morphine withdrawal. cognition was evaluated by using the object recognition task. the novel object recogni...
متن کاملThe effect of propranolol and metoprolol on memory performance during morphine withdwal in mice
Beta blockers were used to see if they could prevent the destructive effects of GCs on memory acts. Cognition was evaluated using the object recognition task, the difference in the exploration time between a familial (F) object and a novel (N) object was taken as an index of recognition (RI). Male mice were made dependent by increasing doses of morphine twice daily for three days; RI was assess...
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in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
AM281, Cannabinoid Antagonist/Inverse agonist, Ameliorates Scopolamine-Induced Cognitive Deficit
Objective(s) Cannabinoids have been implicated in memory deficit. We examined the effect of AM281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. Materials and Methods Object recognition task was used to evaluate memory in mice. Exploration time in the first and the second trial was recorded. The differences in exploration between a previously...
متن کاملthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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